About sncg and drug resistance

Synuclein-gamma (SNCG): also referred to as Breast Cancer Specific Gene I (BCSG-1), is abnormally expressed at high levels in advanced and metastatic cancers.  It significantly stimulates proliferation, invasion and metastasis of cancer cells and confers cellular resistance to anti-microtubule drugs. 

DRUG RESISTANCE: Chemotherapy with anti-microtubule drugs are the gold-standard, first line chemotherapeutic agents for metastatic cancer treatment and are the most widely prescribed drug class in oncology. Anti-microtubule drugs such as taxanes is widely used to treat advanced breast cancer when used in combination with other medications. Taxanes are also used to treat early-stage breast cancer.  Taxanes medications like paclitaxel (brand name: Taxol) and docetaxel (brand name: Taxotere) block cell growth by stopping cell division, helping to bring under control unregulated cell division responsible for breast cancer.   Recent studies demonstrate that BCSG-1 expression in breast cancer cells overrides the mitotic checkpoint control and confers the cellular resistance to anti-microtubule drug-caused apoptosis.  

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